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Glucosamine is a naturally occurring substance found in the body and is a building block of cartilage, the tissue that cushions joints. Glucosamine supplementation is often taken as a dietary supplement for joint health, as it is believed to help with the maintenance and repair of cartilage. Research on glucosamine has shown mixed results, with some studies suggesting that it may provide some benefits for joint pain and stiffness in individuals with osteoarthritis.

Taking glucosamine as a dietary supplement is generally considered safe for most people when used in recommended doses. The recommended daily dose of glucosamine is typically 500-1500 mg per day, taken with a meal. It is important to choose a high-quality glucosamine supplement that has been tested for purity and potency and to follow the manufacturer's recommended usage instructions.

Some people may experience side effects from taking glucosamine, such as upset stomach, heartburn, nausea, diarrhea, or skin reactions. If you experience any adverse effects, it is best to stop taking the supplement and consult with a healthcare professional. Additionally, people with shellfish allergies should be cautious when taking glucosamine as it can be derived from shellfish. 

Certain individuals should avoid taking glucosamine or use it with caution: pregnant and breastfeeding women, diabetics, people with kidney disease, and those on blood-thinning medications.

Glucosamine supplementation is often taken as a dietary supplement to support joint health and to help with the maintenance and repair of cartilage.

A systematic review of clinical trials concluded that there is moderate-quality evidence suggesting that glucosamine may be effective in reducing knee pain in individuals with osteoarthritis, but more research is needed to fully understand its effects.

Glucosamine sulfate is the most commonly studied form of glucosamine for joint health.

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